+- Cruising México (https://cruisingmx.com)
+-- Foro: CRUISIERS MÉXICO (https://cruisingmx.com/forumdisplay.php?fid=1)
+--- Foro: PREGUNTAS Y/O PETICIONES (https://cruisingmx.com/forumdisplay.php?fid=48)
+--- Tema: Barigen 4 mg (Baricitinib) | Medicine Services (/showthread.php?tid=39069)
Barigen 4 mg (Baricitinib) | Medicine Services - iebpharmacy - 01-29-2025
Barigen 4 mg (Baricitinib) is an oral medication primarily used to treat autoimmune and inflammatory conditions. It belongs to the class of Janus kinase (JAK) inhibitors, which help regulate the immune response by targeting specific signaling pathways. Baricitinib is commonly prescribed for rheumatoid arthritis, atopic dermatitis, and certain cases of COVID-19-induced inflammation.
Composition and Mechanism of Action
Each Barigen tablet contains 4 mg of Baricitinib as the active ingredient. Barigen 4 mg (Baricitinib) works by inhibiting Janus kinases (JAK1 and JAK2), enzymes involved in the cytokine signaling process that triggers inflammation. By reducing cytokine activity, Baricitinib helps decrease inflammation, alleviate symptoms, and slow disease progression.
Indications
Barigen 4 mg is prescribed for the treatment of:
Rheumatoid Arthritis (RA): Used in adult patients with moderate to severe RA who have not responded well to conventional disease-modifying antirheumatic drugs (DMARDs).
Atopic Dermatitis: Effective in treating moderate to severe eczema when topical treatments are insufficient.
Alopecia Areata: Helps in hair regrowth by targeting inflammatory pathways responsible for hair loss.
COVID-19: Authorized for emergency use in hospitalized patients with severe COVID-19 to reduce inflammation and improve recovery.
Dosage and Administration
The recommended dose for most indications is 4 mg once daily, taken orally with or without food. However, dosage adjustments may be necessary based on patient-specific factors such as age, renal function, and severity of the disease.
Dosage Adjustments:
Mild to moderate renal impairment: Dose may be reduced to 2 mg daily.
Severe renal impairment: Not recommended.
Elderly patients: Use with caution, as they may be more susceptible to side effects.
Contraindications
Barigen 4 mg is contraindicated in:
Patients with known hypersensitivity to Baricitinib or any of its excipients.
Individuals with severe liver impairment.
Patients with active tuberculosis or other serious infections.
Pregnant and breastfeeding women unless deemed necessary by a physician.
Warnings and Precautions
Risk of Serious Infections: Patients using Baricitinib are at an increased risk of infections, including tuberculosis, bacterial, viral, and fungal infections.
Thrombosis Risk: Increased risk of deep vein thrombosis (DVT) and pulmonary embolism (PE); monitor for symptoms such as swelling, pain, and difficulty breathing.
Hepatic Impairment: Liver function should be monitored regularly, as Baricitinib may elevate liver enzyme levels.
Malignancy and Lymphoproliferative Disorders: There is a potential risk of cancer, especially in long-term use.
Gastrointestinal Perforation: Cases of intestinal perforation have been reported; caution is advised in patients with a history of diverticulitis.
Side Effects
Common side effects of Barigen 4 mg include:
Mild Effects: Nausea, headache, upper respiratory tract infections, increased cholesterol levels.
Serious Effects: Serious infections, blood clots, liver enzyme elevation, neutropenia, and thrombocytopenia.
Patients experiencing severe allergic reactions, such as difficulty breathing, swelling, or rash, should seek immediate medical attention.
Drug Interactions
Barigen 4 mg may interact with:
Biologic DMARDs (e.g., TNF inhibitors): Increases risk of infections and should not be used in combination.
CYP3A4 Inhibitors (e.g., Ketoconazole): May increase Baricitinib levels and toxicity risk.
Immunosuppressants (e.g., Cyclosporine, Tacrolimus): Potential for excessive immune suppression and increased infection risk.
Storage and Handling
Store at room temperature (15-30°C) in a dry place.
Keep out of reach of children.
Do not use expired medication.
Conclusion
Barigen 4 mg (Baricitinib) is a potent JAK inhibitor used for managing autoimmune conditions like rheumatoid arthritis, atopic dermatitis, and alopecia areata, as well as severe COVID-19 cases. While highly effective, it requires careful monitoring due to the risk of infections, blood clots, and other adverse effects. Always consult a healthcare provider before use to ensure safety and efficacy.